Regulation of heterochromatin remodelling and myogenin expression during muscle differentiation by FAK interaction with MBD2
نویسندگان
چکیده
منابع مشابه
Regulation of heterochromatin remodelling and myogenin expression during muscle differentiation by FAK interaction with MBD2.
Focal adhesion kinase (FAK), a major cell adhesion-activated tyrosine kinase, has an important function in cell adhesion and migration. Here, we report a new signalling of FAK in regulating chromatin remodelling by its interaction with MBD2 (methyl CpG-binding protein 2), underlying FAK regulation of myogenin expression and muscle differentiation. FAK interacts with MBD2 in vitro, in myotubes, ...
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15 صفحه اولFAK-dependent regulation of myofibroblast differentiation.
Fibroblasts and myofibroblasts both participate in wound healing. Transforming growth factor beta (TGFbeta) induces fibroblasts to differentiate into myofibroblasts, whereas fibroblast growth factor and heparin (FGF/h) induce myofibroblasts to "de-differentiate" into fibroblasts. TGFbeta induces expression of smooth muscle alpha actin (SMalphaA) and incorporation into in stress fibers, a phenot...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2009
ISSN: 0261-4189,1460-2075
DOI: 10.1038/emboj.2009.178